TABLE 1.
Unlabeled MAb | % Inhibition of biotin-labeled MAbs
|
Site | ||||||
---|---|---|---|---|---|---|---|---|
M953 | M957 | M974 | M960 | M962 | M965 | M971 | ||
M953 | 99 | 91 | 98 | 29 | 70 | 63 | 7 | I |
M954 | 94 | 75 | 83 | 22 | 47 | 38 | 9 | |
M955 | 59 | 50 | 30 | 13 | 26 | 25 | 0 | |
M956 | 99 | 91 | 99 | 7 | 49 | 48 | 0 | |
M957 | 99 | 93 | 99 | 10 | 47 | 44 | 0 | |
M973 | 99 | 96 | 99 | 29 | 66 | 58 | 12 | |
M974 | 97 | 84 | 94 | 29 | 54 | 50 | 16 | |
M975 | 99 | 92 | 99 | 2 | 42 | 31 | 0 | |
M958 | 20 | 11 | 11 | 70 | 17 | 23 | 4 | II |
M960 | 20 | 21 | 7 | 70 | 16 | 17 | 0 | |
M961 | 17 | 14 | 10 | 67 | 16 | 24 | 2 | |
M966 | 20 | 2 | 7 | 55 | 19 | 21 | 0 | |
M976 | 25 | 6 | 11 | 64 | 19 | 24 | 13 | |
M977 | 20 | 13 | 14 | 67 | 20 | 13 | 13 | |
M951 | 24 | 17 | 10 | 0 | 54 | 59 | 0 | III |
M959 | 45 | 35 | 12 | 0 | 99 | 99 | 0 | |
M962 | 41 | 27 | 22 | 4 | 99 | 99 | 0 | |
M964 | 52 | 27 | 24 | 6 | 98 | 99 | 0 | |
M965 | 43 | 27 | 18 | 0 | 98 | 99 | 0 | |
M967 | 45 | 28 | 17 | 7 | 99 | 99 | 0 | |
M970 | 42 | 20 | 11 | 0 | 98 | 99 | 0 | |
M972 | 54 | 28 | 21 | 22 | 99 | 99 | 7 | |
M963 | 16 | 0 | 9 | 24 | 21 | 21 | 98 | IV |
M968 | 27 | 11 | 5 | 15 | 21 | 26 | 97 | |
M969 | 5 | 1 | 0 | 12 | 25 | 22 | 98 | |
M971 | 24 | 0 | 12 | 15 | 21 | 15 | 96 | |
M978 | 11 | 0 | 7 | 0 | 16 | 24 | 88 |
Each value represents the percent inhibition of the biotin-labeled MAb by the unlabeled MAb. Boxed areas enclose those MAbs recognizing a single antigenic site.