Table 2.

The incidence of MTX and LEF discontinuation

	MTX			LEF
Outcome	Events (n)	Person-time (years)	Event rate (95% CI) /1000 person-years	Events (n)	Person-time (years)	Event rate (95%CI) /1000 person-time
Any reason
Ever	3584	46 571	76.96 (74.48, 79.52)	946	4,558	207.54 (194.73, 221.20)
First 12 months	2185	12 327	177.25 (169.97, 184.84)	765	1,593	480.10 (447.26, 515.36)
After 12 months	1399	34 244	40.85 (38.81, 43.00)	181	2,965	61.05 (53.01, 70.30)
With any blood-test abnormality
Ever	1262	45 435	27.78 (26.29-29.35)	259	4,449	58.22 (51.55, 65.76)
First 12 months	517	12 239	42.24 (38.75, 46.05)	168	1,577	106.53 (91.58, 123.92)
After 12 months	745	33 196	22.44 (20.90, 24.09)	91	2,872	31.69 (25.89, 38.79)
With severe blood-test abnormality
Ever	170	46 466	3.66 (3.15, 4.25)	28	4,548	6.16 (4.25, 8.92)
First 12 months	73	12 317	5.93 (4.71, 7.45)	15	1,592	9.42 (5.68, 15.63)
After 12 months	97	34 149	2.84 (2.32, 3.47)	13	2,956	4.40 (2.56, 7.56)