Table 4.
Incidence of MTX and LEF dose reduction
| MTX |
LEF |
|||||
|---|---|---|---|---|---|---|
| Outcome | Events (n) | Person-time (years) | Event rate (95% CI) /1000 person-years | Events (n) | Person-time (years) | Event rate (95%CI) /1000 person-time |
| Any abnormal blood-test result | ||||||
| Ever | 142 | 6679 | 21.26 (18.04, 25.06) | 47 | 3151 | 14.92 (11.21, 19.85) |
| First 12 months | 77 | 2764 | 27.86 (22.29, 34.84) | 31 | 1176 | 26.36 (18.54, 37.48) |
| After first 12 months | 65 | 3915 | 16.60 (13.05, 21.13) | 16 | 1975 | 8.10 (4.97, 13.20) |
| Leucopenia (WBC <3.5×109/l) | ||||||
| Ever | 36 | 6785 | 5.31 (3.83, 7.36) | 19 | 3185 | 5.97 (3.80, 9.35) |
| First 12 months | 19 | 2779 | 6.84 (4.36, 10.72) | 14 | 1181 | 11.85 (7.02, 20.02) |
| After first 12 months | 17 | 4006 | 4.24 (2.64, 6.82) | 5 | 2004 | 2.50 (1.04, 5.99) |
| Neutropenia (Neutrophil <1.6×109/l) | ||||||
| Ever | 21 | 6798 | 3.09 (2.01, 4.74) | 23 | 3177 | 7.24 (4.81, 10.89) |
| First 12 months | 14 | 2779 | 5.04 (2.98, 8.51) | 13 | 1182 | 11.00 (6.39, 18.94) |
| After first 12 months | 7 | 4019 | 4.24 (2.64, 6.82) | 10 | 1995 | 5.04 (2.71, 9.35) |
| Thrombocytopenia (Platelet <140×109/l) | ||||||
| Ever | 26 | 6784 | 3.83 (2.61, 5.63) | 9 | 3200 | 2.81 (1.46, 5.41) |
| First 12 months | 11 | 2782 | 3.95 (2.19, 7.14) | 8 | 1183 | 6.77 (3.38, 13.53) |
| After first 12 months | 15 | 4002 | 3.75 (2.26, 6.21) | –/– | –/– | 0.50 (0.07, 3.52) |
| ALT or AST >100 IU/l | ||||||
| Ever | 56 | 6758 | 8.29 (6.38, 10.77) | 9 | 3197 | 2.82 (1.46, 5.41) |
| First 12 months | 31 | 2776 | 11.17 (7.85, 15.88) | 7 | 1184 | 5.91 (2.82, 12.40) |
| After first 12 months | 25 | 3982 | 6.28 (4.25, 9.28) | –/– | 2013 | 1.00 (0.25, 3.97) |
| CKD progression/creatinine + >26 μmol/l | ||||||
| Ever | 33 | 6787 | 4.86 (3.46, 6.84) | 6 | 3199 | 1.88 (0.84, 4.17) |
| First 12 months | 19 | 2777 | 6.84 (4.36, 10.73) | –/– | –/– | 1.69 (0.42, 6.76) |
| After first 12 months | 14 | 4010 | 3.49 (2.07, 5.89) | –/– | –/– | 1.99 (0.75, 5.28) |
WBC: white blood cells