Fig. 4.

SARM expression by RA monocytes inversely correlates with disease activity

Expression of (A) SARM1 (n = 22), (B) PYCARD (n = 22), (C) CASP1 (n = 22) and (D) NLRP3 (n = 22) in monocytes isolated from RA patients correlated to the DAS28. Significance was analysed using a two-tailed Pearson’s test (*P = 0.0246). (E) SARM protein expression in monocytes from HC and RA patients with a range of DAS28 scores was analysed by western blot with GAPDH as a loading control. DAS28: disease activity score in 28 joints; HC: healthy controls; SARM: sterile-α and armadillo motif containing protein.