Table 1.
Antimicrobial activities of AuNP loaded with some of the FDA-approved drugs
| Drug | Drug type | Core sizes (nm) | Shape | Test microorganisms | Ref |
|---|---|---|---|---|---|
| Ciprofloxacin | Antibiotic | 15 | Gold silica nanoshells |
E. coli DH5α Lactococcus lactis |
[152] |
| Cefaclor | Antibiotic | 23–52 | Spheres |
S. aureus E. coli |
[149] |
| Lincomycin | Antibiotic |
S. aureus S. pyogenes |
[4] | ||
| Vancomycin | Antibiotic | Vancomycin-resistant strains (VRE) | [150] | ||
| Ampicilin | Antibiotic | 1.43 | Spheres assembled into rosette nanotube |
S. aureus MRSA |
[151] |
| Rifampicin | Antibiotic | 28 | Spheres | N/T | [153] |
| Kanamycin | Antibiotic | 20 | Spheres |
Streptococcus bovis (S. bovis) Staphylococcus epidermidis (S. epidermidis) Enterobacter aerogenes (E. aerogenes) Pseudomonas aeruginosa (P. aeruginosa) Yersinia pestis (Y. pestis) |
[21] |
| 4,6-diamino-2-pyrimidinethiol (DAPT) | Inactive alone | 5 / 16.57 | Spheres |
S. aureus E. coli P. aeruginosa E. coli infected mice |
[13, 112] |
| 5FU | Anti-leukemic drug | 18 | Spheres |
Micrococcus luteus S. aureus P. aeruginosa E. coli Aspergillus fumigatus Aspergillus niger |
[58] |
| Metformin | Anti-hyperglycemic drug | 3.1 |
S. aureus E. coli P. aeruginosa |
[13] |
N/T not tested