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The change of immune microenvironment with ACLF development. (A) CIBERSORT cellular composition analysis revealed relative fractions of different immune cell types varied across ACLF development. (B) The relative fraction changes of immune cell types associated with ACLF rat progression. *P < 0.05, **P < 0.01, ***P < 0.001. ACLF, acute-on-chronic liver failure; LC, liver cirrhosis; NC, normal control; NK, natural killer.
