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Identification of the CIMP in 184 PC patients. Heat map of expression of 72 overall survival-related CpGs in three methylation clusters (a); three methylation clusters (CIMP-L subgroup (n = 46), CIMP-M subgroup (n = 82), and CIMP-H subgroup (n = 56)) were generated via k-means consensus clustering (b); principal component analysis of 184 PC patients clustered as 3 subgroups (c); and Kaplan–Meier analysis of OS and PFS time among patients with different CIMP statuses (d-e).
