Table 2.

Univariate and multivariate analyses of overall survival and progression-free survival in PAAD patients of the TCGA cohort.

Variables	OS						PFS
	Univariate analysis			Multivariate analysis			Univariate analysis			Multivariate analysis
	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
Gender
(Male vs. female)	0.84	0.565–1.25	0.39				0.929	0.637–1.354	0.701
Age
(>65 vs. ≤ 65)	1.302	0.873–1.943	0.195				1.237	0.843–1.815	0.277
T stage
(T3 + T4 vs. T1 + T2)	2.28	1.179–4.407	0.014∗	1.584	0.796–3.15	0.19	2.651	1.406–4.999	0.003∗	2.037	1.053–3.942	0.035∗
N stage
(N1 + Nx vs. N0)	2.117	1.278–3.508	0.004∗	1.828	1.096–3.049	0.021∗	1.603	1.035–2.482	0.034∗	1.48	0.946–2.316	0.086
M stage
(M1 + Mx vs. M0)	0.844	0.567–1.257	0.404				0.58	0.396–0.851	0.005∗	0.725	0.491–1.0	0.105
TNM stage
(stage III + IV vs. stage I + II)	1.0	0.31–3.225	1.0				0.994	0.461–2.154	0.994
CIMP status
CIMP-M vs. CIMP-L	2.039	1.142–3.642	0.016∗	1.72	0.948–3.122	0.074	1.585	0.934–2.688	0.088
CIMP-H vs. CIMP-L	2.289	1.245–4.206	0.008∗	2.043	1.096–3.806	0.024∗	2.393	1.405–4.075	0.001∗	1.956	1.129–3.388	0.017∗