Table 3.
Expression of 59 kinds of chemokine among PC patients with different CIMP statuses.
| Gene | CIMP-L (N = 46) | CIMP-M (N = 76) | CIMP-H (N = 56) | P value | |||
|---|---|---|---|---|---|---|---|
| Mean | Sd | Mean | Sd | Mean | Sd | ||
| CCL1 | 0.019 | 0.034 | 0.021 | 0.037 | 0.020 | 0.045 | 0.941 |
| CXCR6 | 2.238 | 1.739 | 1.344 | 1.406 | 0.669 | 0.483 | <0.001∗∗∗ |
| CCL2 | 35.294 | 33.754 | 19.973 | 17.815 | 11.123 | 9.482 | <0.001∗∗∗ |
| CCL19 | 89.272 | 118.604 | 52.134 | 78.701 | 16.316 | 27.712 | <0.001∗∗∗ |
| XCL2 | 1.092 | 0.904 | 0.696 | 0.675 | 0.446 | 0.439 | <0.001∗∗∗ |
| CX3CL1 | 11.107 | 6.235 | 14.391 | 10.037 | 15.302 | 17.829 | 0.207 |
| CCR10 | 0.616 | 1.214 | 0.360 | 0.212 | 0.298 | 0.183 | 0.033∗ |
| CCL25 | 0.224 | 0.518 | 2.914 | 14.716 | 0.225 | 1.103 | 0.188 |
| CXCR4 | 86.490 | 125.355 | 57.819 | 71.923 | 31.478 | 18.115 | 0.003∗∗ |
| CCL28 | 7.608 | 8.420 | 7.050 | 6.102 | 6.124 | 4.299 | 0.483 |
| CXCL2 | 13.775 | 24.638 | 9.186 | 7.417 | 7.984 | 24.495 | 0.284 |
| CCR2 | 2.095 | 1.697 | 1.318 | 1.272 | 0.603 | 0.563 | <0.001∗∗∗ |
| CCL5 | 32.342 | 26.573 | 23.419 | 21.406 | 13.148 | 10.918 | <0.001∗∗∗ |
| CCR9 | 0.185 | 0.186 | 0.248 | 0.333 | 0.248 | 0.225 | 0.402 |
| XCR1 | 0.636 | 0.602 | 0.341 | 0.432 | 0.148 | 0.224 | <0.001∗∗∗ |
| CCL8 | 1.405 | 1.377 | 1.051 | 1.784 | 0.751 | 1.491 | 0.123 |
| CXCL11 | 2.560 | 3.744 | 3.279 | 6.261 | 2.675 | 4.345 | 0.697 |
| CXCL1 | 18.895 | 26.105 | 16.609 | 12.493 | 15.503 | 28.623 | 0.742 |
| CXCL17 | 26.545 | 34.664 | 62.098 | 85.526 | 64.257 | 86.579 | 0.022∗ |
| CXCR5 | 0.229 | 0.490 | 0.120 | 0.292 | 0.028 | 0.051 | 0.007∗∗ |
| CCL16 | 0.141 | 0.109 | 0.084 | 0.065 | 0.038 | 0.041 | <0.001∗∗∗ |
| CCR5 | 3.709 | 2.898 | 2.485 | 2.357 | 1.251 | 0.993 | <0.001∗∗∗ |
| CXCL8 | 18.044 | 18.167 | 25.857 | 27.721 | 16.058 | 16.663 | 0.031∗ |
| CXCL14 | 62.254 | 72.601 | 97.927 | 80.887 | 132.875 | 168.641 | 0.009∗∗ |
| CCR8 | 0.536 | 0.583 | 0.446 | 0.435 | 0.307 | 0.366 | 0.040∗ |
| CCL15 | 1.298 | 1.478 | 1.786 | 2.572 | 1.556 | 2.122 | 0.491 |
| CCL21 | 108.128 | 193.077 | 72.864 | 195.196 | 24.227 | 43.603 | 0.034∗ |
| CCL23 | 1.964 | 1.921 | 1.821 | 3.553 | 0.828 | 1.388 | 0.049∗ |
| CCR7 | 8.640 | 15.561 | 4.779 | 12.140 | 1.401 | 1.492 | 0.006∗∗ |
| CCL3 | 3.676 | 3.275 | 2.509 | 1.904 | 1.737 | 1.501 | <0.001∗∗∗ |
| CCL7 | 0.290 | 0.598 | 0.386 | 0.491 | 0.529 | 0.928 | 0.203 |
| CXCL10 | 10.127 | 15.566 | 11.441 | 24.734 | 9.581 | 13.448 | 0.854 |
| CCL24 | 3.600 | 3.986 | 23.088 | 85.332 | 20.610 | 94.433 | 0.372 |
| CX3CR1 | 1.521 | 1.261 | 1.015 | 0.941 | 0.576 | 0.733 | <0.001∗∗∗ |
| CCL4 | 4.747 | 3.162 | 2.978 | 2.468 | 1.757 | 1.277 | <0.001∗∗∗ |
| CCL22 | 4.591 | 5.368 | 3.777 | 3.472 | 2.011 | 1.733 | 0.002∗∗ |
| CXCL13 | 21.519 | 45.303 | 14.589 | 37.830 | 4.694 | 11.043 | 0.046∗ |
| CXCR2 | 0.684 | 0.870 | 0.648 | 0.801 | 0.217 | 0.310 | 0.002∗∗ |
| CXCL6 | 11.406 | 16.524 | 10.446 | 13.190 | 5.032 | 4.956 | 0.015∗ |
| CCL14 | 1.066 | 0.998 | 0.577 | 0.508 | 0.162 | 0.145 | <0.001∗∗∗ |
| CCL26 | 3.888 | 9.430 | 3.928 | 16.757 | 1.956 | 3.101 | 0.606 |
| CCR4 | 2.337 | 2.796 | 1.304 | 1.546 | 0.520 | 0.547 | <0.001∗∗∗ |
| CCL17 | 10.386 | 19.405 | 8.800 | 11.544 | 3.906 | 5.125 | 0.025∗ |
| CXCR1 | 0.662 | 0.839 | 0.646 | 0.819 | 0.288 | 0.357 | 0.008∗∗ |
| CCR1 | 5.030 | 3.568 | 3.859 | 3.112 | 2.588 | 1.995 | <0.001∗∗∗ |
| CXCL5 | 38.527 | 64.259 | 81.274 | 124.396 | 36.474 | 49.043 | 0.008∗∗ |
| CXCL9 | 18.918 | 42.376 | 14.706 | 50.569 | 9.541 | 19.449 | 0.511 |
| XCL1 | 0.452 | 0.345 | 0.409 | 0.472 | 0.377 | 0.674 | 0.766 |
| CXCR3 | 2.298 | 2.170 | 2.379 | 2.067 | 1.941 | 1.557 | 0.424 |
| CCL18 | 21.990 | 42.000 | 29.714 | 29.962 | 15.548 | 23.234 | 0.041∗ |
| CCL13 | 4.006 | 5.276 | 4.984 | 4.601 | 4.791 | 7.459 | 0.655 |
| CCR6 | 0.141 | 0.194 | 0.098 | 0.117 | 0.049 | 0.057 | 0.002∗∗ |
| CCR3 | 0.086 | 0.101 | 0.110 | 0.159 | 0.147 | 0.449 | 0.522 |
| CXCL16 | 38.590 | 19.162 | 48.610 | 16.384 | 49.334 | 14.780 | 0.002∗∗ |
| CCL20 | 8.951 | 12.180 | 25.344 | 41.318 | 19.521 | 29.584 | 0.027∗ |
| CCL11 | 3.908 | 3.675 | 3.800 | 3.876 | 1.647 | 1.317 | <0.001∗∗∗ |
| CCL27 | 0.000 | 0.003 | 0.000 | 0.000 | 0.001 | 0.005 | 0.300 |
| CXCL3 | 4.555 | 9.367 | 5.720 | 6.384 | 5.472 | 13.359 | 0.811 |
| CXCL12 | 25.525 | 16.445 | 12.292 | 10.336 | 4.826 | 3.670 | <0.001∗∗∗ |