Table 1.
In-vitro anti-proliferative effects with IC50 values of the isolated compounds (1, 2, 4, 5, and 6) on HeLa cell line.
| Compound No. | Concentration (μg/mL) | % of inhibition against in HeLa cell line | IC50 value (μg/mL) |
|---|---|---|---|
| Methotrexate | 62.5 | 30.3 | 36.5 |
| 125 | 53.4 | ||
| 250 | 94.8 | ||
| 1 | 62.5 | 21.45 | 181.3 |
| 125 | 26.68 | ||
| 250 | 70.14 | ||
| 500 | 72.86 | ||
| 2 | 62.5 | 5.28 | 194.4 |
| 125 | 28.53 | ||
| 250 | 67.84 | ||
| 500 | 83.3 | ||
| 4 | 62.5 | 3.38 | 252.14 |
| 125 | 4.17 | ||
| 250 | 63.63 | ||
| 500 | 73.47 | ||
| 5 | 62.5 | 1.88 | 298.86 |
| 125 | 4.87 | ||
| 250 | 34.55 | ||
| 500 | 74.49 | ||
| 6 | 62.5 | 1.58 | 265.07 |
| 125 | 9.15 | ||
| 250 | 60.54 | ||
| 500 | 68.75 | ||
| Control (DMSO) | 2.5 | – | – |
Note: DMSO = Dimethyl sulfoxide.