Table 1.

Relationship between biochemical variables (outcome) and CGG repeats, separately for FXTAS and Non-FXTAS assessed by robust regression.

	FXTAS				Non-FXTAS
	N	Coef	se	p *	N	Coef	se	p*
Relative AMPK activity+	19	1.85	0.96	0.054	28	0.30	0.33	0.364
TORC1 activity+	16	0.10	0.14	0.459	17	0.17	0.33	0.616
Mitochondrial mass+	10	−0.27	0.09	0.004*	15	0.10	0.03	0.001*
ROS+	10	0.26	0.82	0.753	15	−0.41	0.10	<0.001*
Basal respiration rate	17	3.00	1.72	0.081	26	−1.69	0.65	0.009
ATP Synthesis	17	1.32	1.36	0.332	26	−1.15	0.49	0.019
Non-mitochondrial ATP OCR	17	0.99	0.23	<0.001*	26	−0.28	0.20	0.169
Proton Leak OCR	17	0.46	0.36	0.195	26	−0.34	0.20	0.077
ATP steady state level+	18	0.84	1.01	0.409	27	−0.88	0.33	0.008
			Kernel density estimate of distribution of CGG repeat numbers for FXTAS and non-FXTAS subgroups separately.

Analyses were conducted using robust linear regression; N, sample size; p, p-value; +Estimated regression coefficient (Coef) and standard error (se) were multiplied by 100;

^*adjusted p-value remained < 0.05 after adjustment for multiple testing using Bonferroni correction method. Bold figures indicate significant relationships prior to adjustment for multiple testing.