Table 3B.
Relationships between SCL90 scores and cellular stress sensing and bioenergetics measures in FXTAS sample.
| Relative AMPK activity | TORC1 activity | Mitochondrial mass | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Coef | se | p | N | Coef | se | p | N | Coef | se | p | |
| SCL90 depression T score | 12 | 1.27 | 3.60 | 0.725 | 10 | −9.48 | 28.3 | 0.738 | 5 | −15.0 | 47.3 | 0.751 |
| SCl90 anxiety T score | 12 | 1.26 | 3.85 | 0.743 | 10 | 6.30 | 37.1 | 0.865 | 5 | −17.9 | 14.9 | 0.229 |
| SCL90 GSI T score | 12 | 0.88 | 2.09 | 0.675 | 10 | 2.18 | 13.3 | 0.870 | 5 | −23.7 | 59.3 | 0.690 |
| ROS | Basal respiration rate+ | ATP Synthesis+ | ||||||||||
| SCL90 depression T score | 5 | −18.6 | 20.0 | 0.352 | 11 | 6.81 | 1.66 | <0.001* | 11 | 4.47 | 3.46 | 0.197 |
| SCL90 anxiety T score | 5 | −41.8 | 11.6 | <0.001* | 11 | 4.41 | 0.67 | <0.001* | 11 | 5.44 | 0.84 | <0.001* |
| SCL90 GSI T score | 5 | −21.8 | 14.6 | 0.134 | 11 | 4.62 | 0.99 | <0.001* | 11 | 3.26 | 2.92 | 0.264 |
| Non-mitochondrial ATP OCR+ | Proton Leak OCR+ | ATP steady state level | ||||||||||
| SCL90 depression T score | 11 | 28.7 | 5.03 | <0.001* | 11 | 20.4 | 13.2 | 0.121 | 12 | 3.68 | 5.15 | 0.475 |
| SCL90 anxiety T score | 11 | 11.0 | 3.09 | < 0.001* | 11 | 17.7 | 9.58 | 0.065 | 12 | 1.56 | 4.28 | 0.715 |
| SCL90 GSI T score | 11 | 15.6 | 1.81 | <0.001* | 11 | 16.8 | 9.15 | 0.066 | 12 | 1.79 | 3.09 | 0.563 |
N = sample size; p = p-value; +Estimated regression coefficient (Coef) and standard error (se) were multiple by 100. *p-value remained <0.05 after adjustment for multiple testing using Bonferroni correction. Bold figures indicate significant relationships prior to adjustment for multiple testing. SCL90 scale scores (not adjusted for age or gender) are the outcome, and cellular measures are predictors in robust regression analysis.