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. 2021 Nov 22;11:777834. doi: 10.3389/fonc.2021.777834

Figure 2.

Figure 2

ER-α agonist exposure improves survival and decreases tumor burden (A) Gross images of livers from mice upon sacrifice show notable macroscopic disease in all groups. H&E staining of representative liver sections from the three groups in both male and female mice. Control group livers show more malignant nodules infiltrating the tissue. The agonist groups have smaller foci of tumor nodules (Magnification: 100X). (B) Kaplan-Meier curve comparing survival of HCC control mice (N = 4) and mice injected with ER-α agonist (N=6) or antagonist (N = 6). Agonist mice show significantly increased survival as compared to the control groups. p < 0.0001, Gehan-Breslow-Wilcoxon test. (C) Bar plot depicting tumor burden expressed as percentage of tumor cells in the liver tissue. Control groups livers show a higher percentage of infiltrating malignant cells. Mean with SD values are represented in the graph. *P < 0.05, multiple t-test. SD, standard deviation.