Figure 1.

Results of polygenic risk prediction for Problematic Alcohol Use (PAU) plotted on the cortex. The results are shown for those modalities that had significant regions in the Desikan atlas after controlling for mean of the modality, prenatal alcohol exposure, age, sex, age by sex, first 20 principal components, SES, and accounting for family and site as random nested effects. Red indicates areas where higher PAU polygenic risk predicted more of that modality. In the top panel, we focus on supramarginal gyrus cortical thickness prediction by PRS, as this association was significant after multiple testing correction. In the bottom panel, we focus on volume of the temporal pole, as this was significantly associated with PAU PRS after multiple testing correction.