Table 2.

Problematic Alcohol Use (PAU) and Drinks Per Week (DPW) PRS Prediction of TopOutcomes in Multiple Linear Model, Accounting for the Other PRS

Region	PAU Beta	PAU P-value	PAU CI	DPW Beta	DPW P-Value	DPW CI
Frontal Pole	−0.0522	0.0060	±0.0371	−0.0129	0.0191	±0.9786
Supramarginal Gyrus	0.0331	0.0025	±0.0355	−0.0034	0.7575	±0.0213

Note. Both the PAU and DPW Polygenic Risk Scores (PRS) were entered as covariates in the same linear mixed effects model to test whether prediction of each outcome was specific to polygenic risk for each alcohol behavior. The standardized beta weights, p-values and confidence intervals around the beta were drawn from the mixed effects regression model. Bold values are those significant in the multiple regression.