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. 2021 Dec 6;20:159. doi: 10.1186/s12943-021-01465-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Identification of potential antigens in KIRC. a Chromosomal distribution of up- and down-regulated genes in KIRC; b Waterfall diagram of the top 30 mutant genes; c Distribution of mutation frequency; d Distribution of mutation number; e Distribution of mutation number of the top 10 genes; f Distribution of mutation frequency of the top 10 genes. g Overlapped genes identified through intersection; h GO enrichment analysis of 572 genes after intersection of overexpressed and mutated genes; i-j Univariate Cox regression analysis of the 37 potential antigens for OS (i) and RFS (j). k Correlation analysis of 37 genes with immune infiltrating cells, red box indicates genes closely related to APCs (threshold: spearman correlation coefficient > 0.3); l Association of TOP2A, MCF4, FMNL1 and DOK3 with B cell, macrophage, and dendritic cells; m Kaplan-Meier curves of the association of TOP2A, MCF4, FMNL1 and DOK3 with OS and DSS. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; OS, overall survival; RFS, recurrence-free survival; DSS, disease specific survival. * p < 0.05 and ** p < 0.01