TABLE 2.

Summary of the outline of the trial design for apatinib DDI simulation

Dosing regimen of apatinib	Co-administered drug	Dosing regimen of co-administered drug		Possible pathway of DDI
750 mg on day 4	Fluvoxamine	50 mg qd	day 1–6	Inhibition	CYP2D6
	Quinidine	200 mg qd
	Paroxetine	30 mg qd
	Erythromycin	250 mg qid			CYP3A4
	Verapamil	120 mg tid
750 mg on day 8	Carbamazepine	400 mg bid	day 1–10	Induction	CYP3A4
	efavirenz	600 mg qd
	phenytoin	300 mg qd