TABLE 3.

Comparison of model-predicted main pharmacokinetic parameters (C_max, T_max, and AUC) to the observed data of apatinib mesylate tablet

Dose level	Parameters	Unit	Predicted	Observed	Fold error
750 mg (in Chinese healthy volunteers)	Tmax	h	2.16	3	0.72
	Cmax	ng/ml	734.76	681	1.08
	AUC	ng/ml·h	5,994.63	7,150	0.84
250 mg (in Chinese healthy volunteers)	Tmax	h	2.16	1.5	1.44
	Cmax	ng/ml	302.47	371	0.82
	AUC	ng/ml·h	2,626.4	2,940	0.89
750 mg (in Chinese cancer patients)	Tmax	h	2.28	2.9	0.79
	Cmax	nM	2,497.76	3,819	0.65
	AUC	nM·h	22,274.01	30,941	0.72