. 2021 Nov 22;12:780937. doi: 10.3389/fphar.2021.780937

TABLE 4.

Comparison of model-predicted C_max and AUC to the observed one in the presence or the absence of inhibitor or inducer

Co-administered drugs	Simulated		Observed		C_max ratio_s/C_max ratio_o	AUC ratio_s/AUC ratio_o
Co-administered drugs	C_max ratio	AUC ratio	C_max ratio	AUC ratio	C_max ratio_s/C_max ratio_o	AUC ratio_s/AUC ratio_o
With itraconazole	2.08	2.69	1.34	1.71	1.55	1.57
With rifampin	0.30	0.28	0.39	0.17	0.77	1.65