TABLE 5.

Simulated exposure changes of apatinib with co-administration of possible inhibitors or inducers

Dosage regime of apatinib	Co-administered inhibitors or inducers	Dosage regime of co-administered drugs		Simulated
				Cmax ratio	AUC ratio
750 mg on day 4	Fluvoxamine	50 mg qd	Days 1–6	1.02	1.02
	Quinidine	200 mg qd		1.15	1.21
	Paroxetine	30 mg qd		1.23	1.29
	Erythromycin	250 mg qid		2.23	3.60
	Verapamil	120 mg tid		1.76	2.17
750 mg on day 8	Carbamazepine	400 mg bid	Days 1–10	0.29	0.30
	Efavirenz	600 mg qd		0.45	0.36
	Phenytoin	300 mg qd		0.37	0.34