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Simulated exposure changes of apatinib in patients with HI and RI
| Subjects | Cmax (ng/ml) | AUC (ng/ml·h) | Ratio | |
|---|---|---|---|---|
| RCmax | RAUC | |||
| HVs | 911.56 | 7,934.66 | / | |
| HI CP-A | 892.54 | 8,641.86 | 1.02 | 1.09 |
| HI CP-B | 1,402.36 | 17,880.77 | 1.54 | 2.25 |
| HI CP-C | 1,524.33 | 24,141.57 | 1.67 | 3.04 |
| Moderate RIs | 894.98 | 8,449.86 | 1.02 | 1.06 |
| Severe RIs | 820.29 | 8,050.40 | 1.11 | 1.01 |
