FIGURE 1.

Nr4a2 structure and binding to target genes. (A) Structural domains of Nr4a2, which include NTD, DBD and LBD. Modulator domains (AF-1 and AF-2) and localization signals (NLS and NES) are also depicted. (B) Nr4a2 DNA-binding sites as monomers at NBRE sites, as dimers (homodimers or heterodimers, not shown) at NurRE sites and as heterodimers with RXR at DR5 sites. AF, activation function; CTD, C-terminal domain; DBD, DNA-binding domain; LBD, ligand-binding domain, NBRE, nerve growth factor-inducible-β-binding response element; NES, nuclear export signal; NLS, nuclear localization signal, NTD, N-terminal domain; NurRE, nur-response element; RXR, retinoic X receptor.