FIGURE 1.

A, Schematic illustration of EpCAM and CD49f expressing extracellular vesicles (EV) isolation from prepared plasma sample using HOMM microfluidic chip. B, Profiling of miRNA extracted from enriched EV using real‐time PCR. Identification of dysregulated miRNA in paired breast cancer and adjacent normal tissues from the TCGA database. Hierarchical clustering using Euclidean distance was performed to graphically show differences in miRNA expression between primary tumor and adjacent normal tissues. C, Evaluation of diagnostic potential of multi‐miRNA panel in EV from breast cancer patients’ plasma. Key driver genes of EV‐miRNA and their carcinogenic function