Table1.

Typical DNA damage checkpoint and repair genes in S. cerevisiae and C. albicans.

Functional Group	S. cerevisiae	C. albicans	Name Description	Function Description
Checkpoint activation
Sensors	DDC2/LCD1	LCD1	Lethal, Checkpoint-defective	Interacts physically with Mec1 and contributes to its activation; uncharacterized in C. albicans.
	DDC1	DDC1	DNA Damage Checkpoint	9–1-1 complex for Mec1 activation; uncharacterized in C. albicans.
	RAD17	RAD17	RADiation sensitive	9–1-1 complex for Mec1 activation; uncharacterized in C. albicans.
	MEC3	MEC3	Mitosis Entry Checkpoint	9–1-1 complex for Mec1 activation; uncharacterized in C. albicans.
	RAD24	RAD24	RADiation senstive	Loads Rad17-Mec3-Ddc1 onto DNA; uncharacterized in C. albicans.
	DPB11	DPB11	DNA Polymerase B (II)	DNA replication initiation protein; prevents accumulation of chromatin bridges by stimulating the Mec1 kinase and suppressing homologous recombination; uncharacterized in C. albicans.
	DNA2	DNA2	DNA synthesis defective	Tripartite DNA replication factor; involved in DNA repair/processing of meiotic DSBs; uncharacterized in C. albicans.
	MRE11	MRE11	Meiotic REcombination	Nuclease subunit of the MRX complex with Rad50 and Xrs2; complex functions in repair of DSBs and in telomere stability.
	RAD50	RAD50	RADiation sensitive	Subunit of MRX complex with Mre11 and Xrs2; complex is involved in processing DSBs.
	XRS2	NA	X-Ray Sensitive	FHA domain-containing component of the Mre11 complex; no ortholog in C. albicans.