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. 2021 Nov 22;8:774824. doi: 10.3389/fmed.2021.774824

Figure 2.

Figure 2

A funnel plot for evaluation of publication bias of (A) total liver injury (TLI), methotrexate discontinuation (MTX-D) and liver fibrosis (LF) in patients with inflammatory bowel disease (IBD), receiving MTX treatment; (B) TLI, MTX-D, and LF in patients with IBD after the trim-and-fill method; (C) TLI, MTX-D, and LF in patients with non-IBD diseases; (D) TLI, MTX-D, and LF in patients with non-IBD diseases after the trim-and-fill method.