Table 4.

Change of parameters from day 1 to day 5

Parameters	Day 1			Day 5			% change from D1 to D5 [median (range); p value2]
	Vitamin D (n = 63)	Placebo (n = 63)	p value1	Vitamin D (n = 63)	Placebo (n = 63)	p value1	Vitamin D (n = 63)	Placebo (n = 63)
SOFA [median (range)]	8 (2–20)	10 (1–21)	0.93	6 (0–20)	7 (0–21)	0.80	−33.33 (−100, 200); 0.17	−20 (−100, 1200); 0.09
Vitamin D (ng/mL)	12.05 ± 6.19	15.47 ± 10.58	0.096	17.73 ± 7.57	16.4 ± 13.47	0.03	50.79 (−32.42, 309.38); <0.0000	5.26 (−91.07, 116.07); 0.11
Ionized Calcium (mmol/L)	1.11 ± 0.15	1.18 ± 0.11	0.0001	1.23 ± 0.18	1.26 ± 0.29	0.95	9.09 (−18.18, 120.0); <0.0000	7.7 (−34.55, 162.5); 0.06
Procalcitonin (ng/mL)	5.79 ± 5.31	5.61 ± 5.82	0.66	4.72 ± 6.31	5.09 ± 6.13	0.66	−26.83 (−98.75, 2900.0); 0.14	−22.22 (−98.28, 1700.0); 0.43

¹Mann–Whitney test;

²Paired t-test