Table 2.
Laboratory parameters of MIS-C cohort
| TOTAL (n = 120) | Clinical phenotype of MIS-C | p value | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Group 1 Shock (n = 63) | Group 2 KD complete (n = 23) | Group 3 No Shock/KD (n = 34) | |||||||
| Evidence of SARS-CoV-2 | |||||||||
| Only antibodypositive* | 94 | (78.3%) | 51 | (81%) | 20 | (87%) | 23 | (67.6%) | |
| RT-PCR positive$ | 19 | (15.8%) | 9 | (14.3%) | 3 | (13%) | 7 | (20.6%) | |
| Epidemiological link | 25 | (20.8%) | 12 | (19%) | 4 | (17.4%) | 9 | (26.5%) | |
| Laboratory values in the first 24 hours, median (IQR) | |||||||||
| Total leukocyte count, x109/L | 12.5 (7.5–19.6) | 13,100 (7,030–20,500) | 11.7 (9.0–18.3) | 9.0 (7–17.8) | 0.397 | ||||
| ANC,x109/L | 9.5 (5.5–15.6) | 11.0 (5.7–16.8) | 9.4 (6.2–12.1) | 6.8 (3.9–12.3) | 0.077 | ||||
| ALC,/μL | 1,912 (892–3,515) | 1,500 (862–3,110) | 2,600 (1,120–4,860) | 2,200 (820–3,636) | 0.166 | ||||
| NL ratio (NLR) | 4.6 (2.2–10.1) | 6.9 (2.9–11.0) | 2.8 (1.5–10.4) | 3.4 (1.9–5.7) | 0.014 | ||||
| Platelet count, x109/L | 170 (106–265) | 120 (52–206) | 247 (162–480) | 195 (158–322) | <0.001 | ||||
| CRP, mg/L | 136 (63.5–212.5) | 160 (78–225) | 113.5 (46.6–196) | 106 (33.5–161) | 0.028 | ||||
| Ferritin, ng/mL | 543 (225–1,127) | 559 (283–977) | 319.5 (139–651) | 250 (122–1,204) | 0.289 | ||||
| D-dimer, ng/mL | 2,075 (1,120–5972) | 3,230 (1,400–7,034) | 710 (460–1,900) | 1,660 (857–6,000) | 0.002 | ||||
| Thrombocytopenia** | 43 (35.8%) | 34 (54%) | 3 (13%) | 6 (17.6 %) | <0.001 | ||||
| Lymphopenia# | 51 (42.5%) | 26 (41.3%) | 11 (47.8%) | 14 (41.1%) | 0.516 | ||||
| Cardiac marker elevated_ | 59/104 (56.7%) | 38/55 (67.2%) | 8/21 (38.1%) | 13/28 (46.4%) | 0.036 | ||||
| ALT>40 IU/L | 64 (53.3%) | 35 (55.6%) | 7 (30.4%) | 22 (64.7%) | 0.034 | ||||
| INR>1.1 | 38 (31.7%) | 25 (39.7%) | 4 (17.4%) | 9 (26.5%) | 0.068 | ||||
ALT, alanine aminotransferase; INR, international normalized ratio; NL ratio, neutrophil-to-lymphocyte ratio; RT-PCR, real-time polymerase chain reaction. *Tested for either total antibody or anti-S1- and anti-S2-specific IgG antibody by chemiluminescent immunoassay (CLIA). $Out of total 19 positive for RT-PCR, 3 were also positive for antibody. **Thrombocytopenia: Platelet count less than 120 x 109/L; #Lymphopenia: Absolute lymphocyte count of less than 1,500/μL in patients 8 months of age or older and of less than 4,500/μL in patients younger than 8 months of age._Increased cardiac markers (troponin-I, CPKMB, NT-ProBNP) were defined on the basis of the hospital cutoff for the upper limit of the normal range