Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 22;9:745897. doi: 10.3389/fcell.2021.745897

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Smith, Nguyen, Rumsey, Long, Shuler and Hickman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Complement activation reduces SKM and NMJ fidelity. SKM fidelity at 2 Hz under direct and indirect stimulation after incubation with 0.05% hCS (N = 2, 6 replicates), non-specific IgG1 (N = 3, 7 replicates), anti-nAChR Ab and a combination of 0.05% hCS (N = 2, 4 replicates) and 2 μg/mL of anti-nAChR Ab (N = 2, 4 replicates). (A) Representative stimulation traces generated at 2 Hz from both direct (SKM stimulation) and indirect (MN stimulation) of a myotube under the five conditions. Mean fidelity of peaks under direct (B) and indirect (C) stimulation. Significant reduction of fidelity with antibody and complement under direct and indirect stimulation and antibody only under indirect stimulation. Statistics: Fisher LSD Method ^∗p < 0.050; ^∗∗p < 0.020; ^∗∗∗p < 0.010.