Table 1.
Mendelian randomization (MR) estimates of CRP and fibrinogen with heart failure.
| Phenotype and methods | IVs (SNPs) | OR (95% CI) | P -value | Q -statistics | P h |
|---|---|---|---|---|---|
| CRP | |||||
| IVW | 41 | 1.01 (0.94–1.09) | 0.77 | 108.8 | <0.001 |
| Weighted median | 41 | 1.02 (0.95–1.08) | 0.64 | ||
| MR-Egger | 41 | 0.93 (0.84–1.02) | 0.15 | ||
| MR-PRESSO | 37 | 1.03 (0.98–1.10) | 0.21 | ||
| Fibrinogen | |||||
| IVW | 19 | 1.21 (0.72–2.06) | 0.46 | 38.2 | 0.004 |
| Weighted median | 19 | 0.94 (0.55–1.58) | 0.80 | ||
| MR-Egger | 19 | 0.67 (0.23–1.96) | 0.15 | ||
| MR-PRESSO | 19 | 1.05 (0.62–1.77) | 0.85 |
CRP, C-reactive protein; IV, instrumental variable; OR, odds ratio; CI, confidence interval; Ph, P for heterogeneity.