Table 2.

Association between IL-1 and IL-6 signaling with heart failure risk estimated in MR analysis.

Biomarker	IVs (SNPs)	OR (95% CI)	P -value
IL-1β	1	1.04 (0.86–1.25)	0.70
IL-1ra	2	0.95 (0.83–1.10)	0.51
Exclude rs4251961	1	1.00 (0.82–1.24)	0.95
IL-6	2	0.86 (0.81–0.91)	<0.001
Exclude rs643434	1	0.89 (0.77–1.03)	0.12
sIL-6r	1	0.96 (0.91–1.01)	0.14

IL-1β, interleukin-1β; IL-1ra, interleukin-1 receptor antagonist; IL-6, interleukin-6; sIL-6r, soluble IL-6 receptor.