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. 2021 Nov 22;12:779085. doi: 10.3389/fimmu.2021.779085

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Copyright © 2021 Ottens and Satterthwaite

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Normal MZ B cell numbers in CD21-cre.IRF4f/f mice. (A, B) Splenocytes from wild type, IRF4-deficient, CD21-cre, and CD21-cre.IRF4f/f mice were stained with antibodies against B220, CD21, and CD23. (A) The frequency of follicular (CD21+CD23+) and MZ (CD21hiCD23lo/-) in the B220+ gate is shown. (B) The total number of MZ B cells gated as in (A) is shown. Data represent mean +/- SD, n = 3-6. **p < 0.01, ns, not significant by Student’s t-test. (C, D) Splenocytes from wild type and IRF4-deficient mice were stained with antibodies against B220, CD93, and CD23. Representative flow cytometry plots are shown in (C), while (D) indicates the frequency of B220+CD93+ transitional cells that lack CD23. Data represent mean +/- SD, n = 6. **p < 0.01 by Student’s t-test.