Table 3.
Association of LVI with overall, disease-free, and metastasis-free survival according to pN0 status and tumor subtypes with or without adjuvant chemotherapy
| Patients | OS |
DFS |
MFS |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | ||||
| All patients | <0.0001 | 1.345 | 1.202 | 1.505 | <0.0001 | 1.312 | 1.201 | 1.432 | <0.0001 | 1.415 | 1.247 | 1.605 |
| Without AC | 0.014 | 1.230 | 1.043 | 1.450 | <0.0001 | 1.293 | 1.136 | 1.471 | 0.024 | 1.271 | 1.033 | 1.563 |
| With AC | <0.0001 | 1.439 | 1.227 | 1.687 | <0.0001 | 1.321 | 1.170 | 1.491 | <0.0001 | 1.480 | 1.259 | 1.740 |
| ER > 0 | <0.0001 | 1.301 | 1.131 | 1.498 | <0.0001 | 1.309 | 1.176 | 1.457 | <0.0001 | 1.322 | 1.130 | 1.547 |
| ER > 0 G1-2 | 0.002 | 1.305 | 1.106 | 1.54 | <0.0001 | 1.32 | 1.165 | 1.494 | 0.002 | 1.362 | 1.125 | 1.649 |
| Without AC | 0.017 | 1.307 | 1.048 | 1.629 | 0.001 | 1.331 | 1.124 | 1.576 | 0.026 | 1.385 | 1.040 | 1.844 |
| With AC | 0.06 | 1.279 | 0.99 | 1.651 | 0.008 | 1.288 | 1.07 | 1.55 | 0.029 | 1.331 | 1.029 | 1.721 |
| ER > 0 G3 | 0.104 | 1.249 | 0.956 | 1.631 | 0.062 | 1.223 | 0.99 | 1.511 | 0.175 | 1.206 | 0.920 | 1.581 |
| HER2− | 0.854 | 0.964 | 0.652 | 1.426 | 0.281 | 1.175 | 0.876 | 1.576 | 0.878 | 1.030 | 0.710 | 1.493 |
| HER2+ | 0.506 | 1.647 | 0.378 | 7.168 | 0.939 | 1.039 | 0.392 | 2.751 | 0.515 | 0.677 | 0.209 | 2.195 |
| Luminal A | 0.134 | 1.227 | 0.939 | 1.602 | 0.030 | 1.230 | 1.020 | 1.483 | 0.460 | 1.117 | 0.833 | 1.497 |
| Without AC | 0.026 | 1.501 | 1.050 | 2.146 | 0.003 | 1.464 | 1.134 | 1.891 | 0.163 | 1.379 | 0.878 | 2.165 |
| With AC | 0.967 | 1.008 | 0.684 | 1.485 | 0.736 | 1.047 | 0.801 | 1.369 | 0.894 | 1.026 | 0.703 | 1.498 |
| ER < 0 | <0.0001 | 1.548 | 1.28 | 1.871 | <0.0001 | 1.425 | 1.221 | 1.663 | <0.0001 | 1.543 | 1.244 | 1.915 |
| ER < 0 | ||||||||||||
| TN | <0.0001 | 1.849 | 1.322 | 2.587 | <0.0001 | 1.646 | 1.26 | 2.149 | 0.001 | 1.853 | 1.294 | 2.653 |
| ER < 0 | ||||||||||||
| HER2+ | 0.011 | 2.406 | 1.227 | 4.718 | 0.018 | 1.791 | 1.103 | 2.907 | 0.019 | 2.239 | 1.140 | 4.390 |
| >2005 | 0.007 | 0.383 | 0.191 | 0.767 | 0.001 | 0.433 | 0.265 | 0.708 | 0.018 | 0.447 | 0.229 | 0.273 |
| pN0 | 0.019 | 1.225 | 1.034 | 1.452 | 0.004 | 1.210 | 1.064 | 1.375 | 0.021 | 1.269 | 1.037 | 1.553 |
Significant values are indicated in bold.
AC, adjuvant chemotherapy; CI, confidence interval; DFS, disease-free survival; ER, estrogen receptor; G, grade; HER2, human epidermal growth factor receptor 2; HR, hazard ratio; LVI, lymphovascular invasion; MFS, metastasis-free survival; OS, overall survival; TN, triple negative.