Table 1.
Overview of all clinical goals used for the optimized plans in this study. Percentages are indicating the relative volume of the ROI and goals are set with a prescription dose of 40.05 Gy. The ROI names follow the nomenclature according to AAPM TG 263 [15]. The clinical goals are based on the consensus statement of the Dutch society for radiation Oncology [18].
| ROI | Description | Goal |
|---|---|---|
| PTVp | PTV of the whole left breast cropped with 5 mm from external | D98% ≥ 38.0 Gy |
| D2% ≤ 42.8 Gy | ||
| 39.6 Gy ≤ Dmean ≤ 40.4 Gy | ||
| PTVn1n2 | PTV of lymph nodes level 1&2 cropped with 5 mm from external | D98% ≥ 38.0 Gy |
| D2% ≤ 42.8 Gy | ||
| PTVn3n4 | PTV of lymph nodes level 3&4 cropped with 5 mm from external | D98% ≥ 38.0 Gy |
| D2% ≤ 42.8 Gy | ||
| Heart | Heart ROI | Dmean ≤ 2.5 Gy |
| Lungs | Lungs ROI | Dmean ≤ 6.0 Gy |
| V5Gy ≤ 50% | ||
| External-PTV | Full patient body, without all PTVs | V42.85y ≤ 10 cm3 |
| Humerus-PRV10 | Humerus ROI with uniform expansion of 10 mm | V38Gy ≤ 2 cm3 |
| Breast_CL | Contralateral breast | Dmean ≤ 1 Gy |
| Thyroid | Thyroid ROI | V30Gy ≤ 50% |
| Esophagus | Esophagus ROI | V30Gy ≤ 5% |