Table 3.
Peptides chosen for synthesis and biological testing and their respective characteristics.
| Characteristic of the peptide | HcP1 a | HcP2 | HcP3 | HcP4 |
|---|---|---|---|---|
| Sequence | FENLGARLL | KPYVLPVPF | ILGDIGILTNATVFT | FAERIHKLVSLGLNI |
| Protein of origin | HSP60 | Enolase | HSP60 | HSC82 |
| Net Charge at pH 7 | Neutral | Neutral | Acid | Basic |
| Molecular weight | 1032.2 g/mol | 1059.31 g/mol | 1547.8 g/mol | 1710.04 g/mol |
| pI | 6.34 | 9.3 | 3.75 | 9.69 |
| 100% similar |
P. brasiliensis
C. immitis B. dermatitidis A. fumigatus |
P. brasiliensis
C. immitis B. dermatitidis S. schenckii A. fumigatus C. neoformans C. auris |
P. brasiliensis
B. dermatitidis |
B. dermatitidis
S. schenckii A. fumigatus |
| % similarity with others | S. schenckii (88.89%) | C. albicans (85.71%) | C. immitis (93.33%) |
P. brasiliensis
C. immitis (93.33%) |
| Subcellular location described in fungi | Mitochondrial and cell wall (35) | Cytosol and cell wall (36). | Mitochondrial and cell wall (35) | Cytoplasmatic (37) |
a
HcP1, H. capsulatum peptide 1.