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. 2021 Nov 22;12:767136. doi: 10.3389/fphys.2021.767136

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Copyright © 2021 Jiang, Guan, Lan, Chen, Li, Zou, Hu and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of Piezo1 hindered the distance of OTM and decreased bone mass. (A) Micro-CT and three-dimensional (3D) reconstruction images showed the distance of OTM. (B) The distance of OTM from day 0 to day 14. The distance was increased by orthodontic force overtime in the OTM group while declined by GsMTx4 in the OTM + INH group. *p < 0.05, the OTM vs. OTM + INH groups. (C) Parameters including bone volume/total volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), and trabecular spacing (Tb.Sp) were examined from day 0 to day 14. BV/TV and Tb.Th of the OTM group were significantly greater than that of the OTM + INH and control (CON) groups on day 14 of OTM. *p < 0.05. Data are presented as the mean ± SD.