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. 2021 Nov 22;9:780187. doi: 10.3389/fbioe.2021.780187

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Copyright © 2021 Cheng, Liu, Li, Liu, Wang, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hemostatic properties of the matrix gel in a pig cardiac puncture injury model. (A) Schematic diagram of the surgical procedure. (B) Gross view of the rapid hemostasis and sealing following cardiac puncture injury. (C) Scanning electron micrographs of the interface between the pig heart puncture wound and the hydrogel. Scale bar: 50 μm (left plates); 10 μm (right plates, enlarged). (D) Images of a heart autopsy following killing after two 2 weeks of postoperative recovery, the hydrogel still adhering to the wound. (E) Tissue staining images of the interface between pig heart cardiac tissue and the matrix gel, after 2 weeks of postoperative recovery. Scale bar: 200 μm (n = 4). Reproduced from (Hong et al., 2019) with permission from Copyright 2019 Springer.