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. 2021 Nov 22;12:764388. doi: 10.3389/fphar.2021.764388

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Copyright © 2021 Liu, Shang, Xiao, Fan, Jiang, Fan and Bai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effect of costunolide (COS) on reserpine-induced neuronal injury. (A). Nissl stain of the zebrafish brain (400×) in periglomerular gray zone (PGZ) (C). Nissl stain of the zebrafish brain (400×) in ventrolateral nucleus of the semicircular torus (TSvl). (B and D) are the quantitative statistics of neurons of the PGZ and TSyl, respectively. (E). The content of 5-HT, DA, NE in zebrafish brain was measured via ELISA. Data are expressed as the mean ± SEM (n = 3/group). Significance was defined as ^# p < 0.05, ^## p < 0.01, ^* p < 0.05, ^** p < 0.01.