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. 2021 Nov 22;9:791892. doi: 10.3389/fcell.2021.791892

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Copyright © 2021 Guo and Piao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The formation and classification of circRNAs. CircRNAs are commonly divided into EIciRNAs, EcircRNAs and ciRNAs in accordance with their components, which were derived from exons and introns, and both of them in pre-mRNAs, respectively. Latant ecircRNAs can be generated from one pre-mRNA via alternative splicing. The red segment and blue segment between Exon 4 and Exon 5 represented a 7-nt GU-rich motif near the 5′ splice site and an 11-nt C-rich motif at the branchpoint site, respectively, which promoted the generation of ciRNAs.