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. 2021 Nov 22;12:730418. doi: 10.3389/fphys.2021.730418

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Copyright © 2021 Köller, Grzegorzewski, Tautenhahn and König.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model overview. (A) Whole-body model. The whole-body PBPK model for ICG consists of venous blood, arterial blood, lung, liver, gastrointestinal tract, and rest compartment (accounting for organs not modeled in detail) and the systemic blood circulation connecting these compartments. (B) Liver model. ICG in the liver plasma compartment is taken up into the liver tissue (hepatocytes). Subsequently hepatic ICG is excreted in the bile from where it is excreted in the feces. No metabolization of ICG takes place in the liver. (C) Modeling liver cirrhosis. Liver cirrhosis was modeled as a combination of tissue loss and hepatic shunts (see main text for details). (D) Modeling hepatectomy. Hepatectomy was modeled as a removal of tissue volume with corresponding vessels (see main text for details).