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. 2021 Nov 22;12:730418. doi: 10.3389/fphys.2021.730418

Figure 2.

Figure 2

Model prediction of ICG time courses in healthy subjects. (A–D) Venous concentration after bolus ICG administration (Klockowski et al., 1990; Grundmann et al., 1992; Andersen et al., 1999; Kamimori et al., 2000). (E) Arterial concentration after bolus ICG administration (Niemann et al., 2000). (F) Venous concentration during an ICG infusion protocol (2.0, 0.5, 1.0 mg/min, 40 min each) (Soons et al., 1991). (G,H) Venous concentration and biliary excretion rate after 3 different ICG doses (0.5, 1.0, 2.0 mg/kg) (Meijer et al., 1988; Chijiiwa et al., 2000). (I) Hepatic venous and arterial concentration during constant ICG infusion (Leevy et al., 1962). (J–L) ICG extraction ratio during constant infusion (Leevy et al., 1962; Grainger et al., 1983).