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. 2021 Nov 22;12:730418. doi: 10.3389/fphys.2021.730418

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Copyright © 2021 Köller, Grzegorzewski, Tautenhahn and König.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dependency of ICG pharmacokinetic parameters on cirrhosis. Simulations of 4 specific cirrhosis degrees are indicated by stars. (A–D) Dependency of ICG pharmacokinetic parameters on the degree of shunting (green), degree of tissue loss (yellow) and degree of cirrhosis (black-blue-red). (E) Correlation between ICG-R20 and ICG-t_1/2 in cirrhotic and control subjects (Cherrick et al., 1960). (F) Correlation between ICG-R20 and ICG-kel in cirrhotic and control subjects (Caesar et al., 1961). (G) Correlation between ICG-PDR after an ICG dose of 0.5 and 5.0 mg/kg in control subjects and subjects with various liver diseases (Leevy et al., 1967). (H) Correlation between ICG-clearance after a bolus administration and during a constant infusion of ICG in cirrhotic subjects (Burns et al., 1991).