Figure 7.

Model prediction of ICG pharmacokinetic parameters in hepatectomy under varying degree of cirrhosis. (A–D) Dependency of postoperative ICG pharmacokinetic parameters on the resected volume in 4 different degrees of cirrhosis. (E) Dependency of postoperative change in ICG-PDR on the resected volume (Stockmann et al., 2009; Thomas et al., 2015). (F) Correlation between the measured postoperative ICG-kel and the estimated postoperative ICG-kel (product of preoperative ICG-kel and the future liver remnant) (Okochi et al., 2002; Ohwada et al., 2006; Sunagawa et al., 2021). (G) Correlation between postoperative ICG-PDR and intraoperative ICG-PDR during trial clamping (Thomas et al., 2015). (H) Correlation between postoperative and preoperative ICG-PDR (Thomas et al., 2015). Simulations for (E–H) were performed for varying resection rates in healthy subjects and three different degrees of cirrhosis.