Table 1.
Overview of curated clinical studies.
| Study | PK-DB | PMID | Protocol | Body weight | Fit | Data used in fit | Description |
|---|---|---|---|---|---|---|---|
| Andersen1999 | PKDB00386 | 10499483 | Bolus: 0.5 mg/kg | Contr.: 83.4 kg; Panc. 58.2 kg | ✓ | ICG time course (plasma) | Pharmacokinetic time course of ICG-disappearance in chronic pancreatitis and healthy subjects. |
| Burns1991 | PKDB00388 | 1848168 | Bolus: 0.5 mg/kg; Infusion: 0.25 mg/min | NR | ✓ | ICG time course (plasma) | ICG pharmacokinetics in healthy subjects and patients with liver disease. |
| Caesar1961 | PKDB00389 | 13689739 | Bolus: 0.5 mg/kg; Infusion: 0.5 mg/min | NR | ✓ | ICG extraction-ratio | Measuring hepatic blood flow and assessing hepatic function by ICG pharmacokinetics. |
| Cherrik1960 | PKDB00390 | 13809697 | Bolus: 0.5 mg/kg | NR | - | - | ICG pharmacokinetics in healthy subjects and patients with liver disease. |
| Chijiiwa2000 | PKDB00391 | 10773154 | Bolus: 0.5 mg/kg | NR | ✓ | ICG time course (bile excretion) | Biliary excretion of ICG and ATP-dependency of ICG pharmacokinetics. |
| Figg1995 | PKDB00393 | 8602375 | Bolus: 0.5 mg/kg | NR | - | - | Comparison of methods to assess hepatic function including CTP-score and ICG-clearance. |
| Gadano1997 | PKDB00394 | 9083919 | Infusion: 0.4 mg/min (controls); 0.8 mg/min (cirrhotics) with priming dose (24 mg controls; 12 mg cirrhotics). | NR | ✓ | - | ICG-clearance and extraction-ratio and their dependency on hepatic bloodflow in healthy subjects and in patients of hepatic fibrosis and cirrhosis. |
| Grainger1983 | PKDB00395 | 6822056 | Bolus: 0.25 mg/kg | NR | ✓ | ICG extraction-ratio | Non-invasive measurement of hepatic blood flow using ICG extraction-ratio. |
| Grundmann1992 | PKDB00396 | 1482735 | Bolus: 0.3 mg/kg | NR | ✓ | ICG time course (plasma) | Effect of anesthetics on ICG-pharmacokinetics and hepatic blood flow. |
| Herold2001 | PKDB00397 | 11169069 | Bolus: 0.5 mg/kg | NR | - | - | Comparison of liver function tests. Correlation between CTP-score and ICG-kel in healthy subjects and cirrhotic patients. |
| Kamimori2000 | PKDB00299 | 10883415 | Bolus: 0.5 mg/kg | 58.6 ± 11.2 kg | ✓ | ICG time course (plasma) | Effect of the menstrual cycle on ICG pharmacokinetics. |
| Keiding1993 | PKDB00402 | 8151094 | Infusion: 0.08 mg/min | NR | - | - | Effect of changing plasma protein concentrations on ICG-extraction. |
| Klockowski1990 | PKDB00403 | 2146057 | Bolus: 0.5 mg/kg | NR | ✓ | ICG time course (plasma) | Effect of isradipine and diltiazem on ICG-pharmacokinetics. |
| Leevy1962 | PKDB00404 | 14463639 | Infusion: 0.3 and 1.5 mg/min/m2 with priming dose (10 mg). | NR | ✓ | ICG extraction-ratio; ICG time course (hv and ar) | Estimation of hepatic blood flow using ICG. |
| Leevy1967 | PKDB00405 | 6071462 | Bolus: 0.5 and 5.0 mg/kg | NR | - | - | Estimation of liver function with ICG. Dose dependency of ICG-PDR. |
| Martin1975 | PKDB00406 | 1208580 | Bolus: 0.5, 2.0, 3.5, and 5.0 mg/kg | NR | - | - | Differences in ICG-pharmacokinetics in men and women at varying ICG-doses. |
| Martin1976 | PKDB00407 | 814028 | Bolus: 0.5, 2.0, 3.5, and 5.0 mg/kg | NR | - | - | ICG-pharmacokinetics in patients with Gilbert's Syndrome. |
| Meijer1988 | PKDB00408 | 3181282 | Bolus: 0.5, 1.0, and 2.0 mg/kg | 64.8 kg | ✓ | ICG time course (plasma and bile excretion) | Biliary excretion of ICG at different doses. |
| Moeller1998 | PKDB00409 | 9691928 | Infusion: Rate not reported | 72.7 (40–115) kg | - | - | Arterial hypoxaemia in cirrhosis. Correlation between ICG-clearance and CTP-score. |
| Moeller2019 | PKDB00410 | 30221390 | Infusion: 0.2 mg/min with priming dose (2 mg), Bolus: 0.5 mg/kg | 79.2 ± 18.5 kg | - | - | Correlation between ICG-pharmacokinetics and CTP-score. |
| Niemann2000 | PKDB00414 | 10801242 | Bolus: 10 mg | 80 ± 17 kg | ✓ | ICG time course (plasma) | ICG- pharmacokinetic time course under administration of propranolol. |
| Ohwada2006 | PKDB00412 | 16498606 | Bolus: 20 mg | NR | - | - | Prediction of postoperative liver functional capacity based on ICG-pharamcokinetics. |
| Okochi2002 | PKDB00415 | 11855925 | Bolus: 20 mg | NR | - | - | Comparison of preoperative and postoperative ICG-pharmacokinetics. Prediction of postoperative liver functional capacity based on ICG-pharamcokinetics. |
| Seyama2009 | PKDB00416 | 19208031 | Bolus: 0.5 mg/kg | NR | - | - | Assessment of liver function for safe hepatic resection. Prediction of survival after hepatectomy based on ICG-R15. |
| Soons1991 | PKDB00411 | 1768562 | Infusion: 2.0, 0.5, 1.0 mg/min (consecutive) | 72 ± 6 kg | ✓ | ICG time course (plasma) | Assessment of hepatic blood flow in healthy subjects by continuous infusion of ICG. |
| Stockmann2009 | PKDB00417 | 19561474 | Bolus: 0.5 mg/kg | NR | - | - | Prediction of postoperative liver functional capacity based on ICG-pharamcokinetics. |
| Sunagawa2021 | PKDB00418 | 33052632 | Bolus: 20 mg | NR | - | - | Prediction of postoperative liver failure based on ICG-kel measurements. |
| Thomas2015 | PKDB00419 | 25581073 | Bolus: 0.25 mg/kg | NR | - | - | Intraoperative prediction of postoperative liver functional capacity using trial-clamping and ICG-pharmacokinetics. |
| Wakabayashi2004 | PKDB00420 | 15013363 | Bolus: 0.5 mg/kg | NR | - | - | Correlation between preoperative ICG-R15 and estimated liver remnant. Prediction of survival based on ICG-R15. |