Table 2.
Overview of fixed model parameters.
| Physiological parameter | Description | Value | Unit | Comment | References |
|---|---|---|---|---|---|
| BW | Body weight | 75 | kg | Reference adult male 73 kg, female 60 kg. Value in typical range. | ICRP, 2002 |
| HEIGHT | Body height | 170 | cm | Reference adult male 176 cm, female 163 cm. Value in typical range. | ICRP, 2002 |
| COBW | Cardiac output per body weight | 0.83 | ml/s/kg | Cardiac output: male 6.5 l/min = 1.48 ml/s/kg (73 kg), female 5.9 l/min = 1.34 ml/s/kg (60 kg); 0.83–1.66 ml/s/kg. Value at lower end of range. | de Simone et al., 1997; ICRP, 2002 |
| HCT | Hematocrit | 0.51 | - | Reference adult male 0.45, female 0.42; 45%. Value at higher end of range | Vander et al., 2001; Herman, 2016 |
| LI__ICGIM_ki_bil | Bilirubin inhibition constant of hepatic ICG uptake | 0.02 | mM | Reference 0.3–0.9 mg/dl = 0.005–0.015 mmole/l | Kawasaki et al., 1988 |
| Fblood | Fraction of organ volume that is blood vessels | 0.02 | - | - | |
| FVgi | Fractional tissue volume gastrointestinal tract | 0.0171 | l/kg | Value from reference. | ICRP, 2002; Jones and Rowland-Yeo, 2013 |
| FVli | Fractional tissue volume liver | 0.021 | l/kg | Value from reference. | ICRP, 2002; Jones and Rowland-Yeo, 2013 |
| FVlu | Fractional tissue volume lung | 0.0297 | l/kg | Value from reference. | ICRP, 2002; Jones and Rowland-Yeo, 2013 |
| FVve | Fractional tissue volume venous blood | 0.0587 | l/kg | Value from reference. | ICRP, 2002; Jones and Rowland-Yeo, 2013 |
| FVar | Fractional tissue volume arterial blood | 0.0184 | l/kg | Value from reference. | ICRP, 2002; Jones and Rowland-Yeo, 2013 |
| FVbi | Fractional tissue volume bile | 0.00071 | l/kg | Value from reference. | ICRP, 2002; Jones and Rowland-Yeo, 2013 |
| FVpo | Fractional tissue volume portal vein | 0.001 | l/kg | Value from reference. | ICRP, 2002; Jones and Rowland-Yeo, 2013 |
| FVhv | Fractional tissue volume hepatic vein | 0.001 | l/kg | Value from reference. | ICRP, 2002; Jones and Rowland-Yeo, 2013 |
| FQgi | Fractional blood flow gastrointestinal tract | 0.19 | - | Value from reference. | ICRP, 2002 |
| FQh | Fractional blood flow hepatic vein | 0.255 | - | Value from reference. | ICRP, 2002 |
| Mr_icg | Molecular weight of ICG | 774.96 | g/mole | Value from reference. | CHEBI:31696 |
| ti_icg | Injection time of ICG | 5 | s | Typical injection times 3–10 s. Value in range. | - |
| Fit parameter | Description | Value | Unit | ||
| LI__ICGIM_Vmax | Vmax of liver import | 0.037 | mmole/min/l | ||
| LI__ICGIM_Km | Km of liver import | 0.0217 | mM | ||
| LI__ICGLI2CA_Vmax | Vmax of bile excretion | 0.000944 | mmole/min/l | ||
| LI__ICGLI2CA_km | Km of bile excretion | 0.0124 | mM | ||
| LI__ICGLI2BI_Vmax | Vmax of bile transport | 0.000114 | 1/min | ||
| Scan parameter | Description | Value | Unit | ||
| f_bloodflow | Scaling factor of hepatic blood flow | 1 | - | ||
| f_cardiac_output | Scaling factor of cardiac output | 1 | - | ||
| f_cirrhosis | Scaling factor of the severity of cirrhosis. Combination of f_shunts and f_tissue_loss | 0 | - | ||
| f_shunts | Fraction of blood shunted around the liver | 0 | - | ||
| f_tissue_loss | Fraction of lost liver tissue | 0 | - | ||
| resection_rate | Fraction of resected liver volume | 0 | - | ||
| LI__f_oatp1b3 | Scaling factor of transport protein amount | 1 | - |