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. 2021 Nov 22;12:765482. doi: 10.3389/fphar.2021.765482

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Copyright © 2021 Shi, Huang, Zhou, Liu, Wu and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pae inhibited LOX expression and vascular fibrosis of in a gut microbiota- dependent manner in ApoE^-/- mice. (A) The expressions of LOX and fibrosis-related indicators (MMP-2/9 and collagen I/III) were examined by western blot in control, HFD, and Pae groups. (B) The expressions of LOX and fibrosis-related indicators (MMP-2/9 and collagen I/III) were examined by western blot in FM(HFD) and FM(Pae) groups. Data are presented as mean ± SEM, n = 3. ^* p < 0.05, ^** p < 0.01.