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. 2021 Nov 22;12:781108. doi: 10.3389/fimmu.2021.781108

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Copyright © 2021 Hildersley, McNeilly, Gillan, Otto, Löser, Gerbe, Jay, Maizels, Devaney and Britton

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conservation and divergence of genes associated with tuft cell function. (A) Dot plot showing log-normalised expression of selected tuft cell genes across clusters. (B) Venn diagram of ovine abomasal and mouse SI tuft cell enriched genes (Log2 fold change >0.5; FDR < 0.05), and genes conserved in human tuft cells from different tissues. Ovine, human and mouse data from this study, and (9, 32), respectively. The four genes conserved in all three species are AVIL, ALOX, ALOX5AP, PTGS1; the 11 genes conserved in sheep and mouse are GNG13, LRMP, LTC4S, RGS13, KRT18, KRT23, BMX, SPIB, SH2D7, TSPAN6, TMEM45B. (C) Violin plot of log-normalised expression of GPCRs across all clusters.