TABLE 1.

Studies depicting presentation and lab values, specifically D‐dimer and LDH values, of COVID‐19 patients

Reference	Author	Year of publication	Type of study	n	SARSCoV2 status	Age (years)	Presenting symptoms	d‐dimer	LDH
4	Kaur P et al	2020	Case report	1	Positive	43	Shortness of breath and acute right leg pain	>20 (reference: <0.5)	718 U/L (reference: 140‐271 U/L)
5	Singh B et al	2020	Case report	1	Positive	77	Shortness of breath and pain, discoloration, and swelling of the left leg	2.77 (reference: <0.5)	392 U/L (reference: 140‐271 U/L)
7	Wang D et al	2020	Retrospective single‐centre case series	138	Positive	56 (mean age)	Fever, fatigue, and dry cough	203 U/L (125‐243) [IQR]	261 U/L [125‐243] [IQR]
8	Guan W et al	2020	Retrospective cohort study	1099	Positive	47 (mean age)	Fever and cough, diarrhoea	No of patients with d‐dimer ≥0.5 mg/L ‐ 46.4% a	No of patients with LDH ≥250 U/L ‐ 41.0%
9	Pan L et al	2020	Descriptive, cross‐sectional, multicentre study	204	Positive	52.9 (mean age)	Digestive manifestations, including lack of appetite, diarrhoea, vomiting, and abdominal pain	N/A	N/A
10	Cheung KS et al	2020	Systematic review and meta‐analysis	59	Positive	58.5 (mean age)	Fever, cough, dyspnoea, diarrhoea, vomiting, abdominal pain/discomfort	N/A	N/A
12	Han C et al	2020	Retrospective cohort study	206	Positive	62.5 (mean age)	Diarrhoea	N/A	N/A
13	Mao R et al	2020	Systematic review and meta‐analysis	6064	Positive	N/A	Nausea, vomiting, diarrhoea, loss of appetite, abdominal pain, fever	N/A	N/A
14	Noda S et al	2021	Case report	1	Positive	17	Abdominal pain, vomiting and fever	2.2 mcg/mL, normal ≤0.5 mcg/mL	N/A
15	Laski D et al	2021	Case report	1	Positive	39	Fever, pain in upper abdomen, nausea, vomiting	N/A	N/A
16	Zeng W et al	2021	Systematic review	5285	Positive	N/A	Diarrhoea, abdominal pain	N/A	N/A
17	Chen N et al	2020	Retrospective, single‐centre study	99	Positive	55.5 (mean age)	Fever, cough, shortness of breath. Muscle ache, diarrhoea	0.9 (normal range 0.0‐1.5)	336.0 (normal range 120.0‐250.0)
18	Kim JY et al	2020	Case report	1	Positive	35	Fever, chills, myalgia	N/A	561 U/L (highest value recorded)
19	Tang A et al	2020	Case report	1	Positive	10	Asymptomatic	N/A	N/A
22	Singh B et al	2021	Systematic review	13	Positive	56 (mean age)	Nausea, vomiting, fever, abdominal pain	N/A	N/A
23	Rodriguez‐Nakamura RM et al	2020	Case report and literature review	2	Positive	43.5 (mean age)	Case 1 ‐ Severe gastric pain	Case 1 ‐ 1450 mcg/L	N/A
							Case 2 ‐ spontaneous abdominal pain	Case 2 – 14 407 mcg/L
25	Ignat M et al	2020	Case series	3	Positive	50.3 (mean age)	Case 1 ‐ Abdominal pain	N/A	N/A
							Case 2,3 ‐ ARDS
26	Paul T et al	2021	Case report	1	Positive	66	Fever, cough, loss of smell and taste	N/A	N/A
27	Swami GA et al	2021	Case report	1	Positive	54	Fever, cough	1245 ng/mL (normal ‐ <250 ng/mL)	745 IU/L (n = 50‐250)
28	Calcagno E‌ et al	2021	Case report	1	Positive	36	Abdominal pain	N/A	N/A
32	Holleb P et al	2021	Case report	1	Positive	54	Nausea, vomiting, abdominal pain, diarrhoea	N/A	N/A
34	Gartland M et al	2020	Case report	1	Positive	47	Fever, shortness of breath	N/A	N/A
35	JHQ Pang et al	2020	Case report	1	Positive	30	Abdominal pain associated with vomiting	d‐dimer >20.0 μg/mL	N/A
36	Al Argan RJ et al	2021	Case series	3	Positive	59.33(mean age)	Case 1 ‐ Dry cough and fever	Case 1 ‐ 0.6	Case 1 ‐ 434
							Case 2 ‐ Shortness of breath	Case 2 ‐ 0.41	Case 2 ‐ 442
							Case 3 ‐ Abdominal pain	Case 3 ‐ 1.66 (Normal ‐ ≤0.5 μg/mL)	Case 3 ‐ 617 (Normal ‐ (81‐234) U/L)
37	Varshney R et al	2021	Case report	1	Positive	50	Abdominal pain and constipation	N/A	N/A
38	Drakos, P. et al	2021	retrospective cohort study	218	Positive	59.8 (mean age)	Listed as acute gastrointestinal injury	Increased based on grading of acute gastrointestinal injury	N/A
33	Cheung S et al	2020	Case report	1	Positive	55	Nausea, vomiting, generalised abdominal pain	3.4 nmol/L	N/A
39	Krothapalli N et al	2021	Case report	1	Positive	76	Shortness of breath	2159 ng/L (normal ‐ <250 ng/mL)	N/A
40	Bannazadeh M et al	2021	Case report	1	Positive	55	Severe abdominal pain	2400 ng/L (normal ‐ <250 ng/mL)	N/A
41	Alharthy A et al	2020	Case report	1	Positive	54	Fever, cough, dyspnea, diarrhoea	4.1 μg/mL; reference range, 0 to 0.5 μg/mL	997 U/L; reference range, 100‐190 U/L)
43	Tang N et al	2020	Retrospective cohort study	449	Positive	65.1 (mean age)	Diarrhoea, acute abdomen	1.94 Reference ‐ 0 to 0.5 μg/mL)	N/A
44	Dinoto E et al	2021	Case report	1	positive	84	Acute abdomen	6937 ng/mL (normal ‐ <250 ng/mL)	431 U/L (n = 50‐250)
45	Balani P et al	2021	Case report	1	Positive	37	Abdominal pain, vomiting	3.1 Reference ‐ 0 to 0.5 μg/mL	N/A
47	Shaikh DH et al	2021	Case report	1	Positive	73	Acute abdomen, distension of abdomen	2757 (normal ‐ <250 ng/mL)	236 (normal = 50‐250)

Abbreviations: IQR, interquartile range; n, no. of patients; N/A, not available.

^a No./total no. (%).