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. 2021 Oct 27;52(1):123–137. doi: 10.1002/eji.202149556

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© 2021 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Memory phenotypes of antigen‐specific AIM+ CD4+ and CD8+ T cells in convalescent SARS‐CoV‐2‐infected children and adults. T_EMRA, T_EM, and T_CM of the antigen‐specific AIM+ CD4+ and CD8+ T cells from the convalescent SARS‐CoV‐2‐infected subjects were enumerated 24 h after the stimulation. Each symbol shows the percentage of T_EMRA (left panels), T_EM (middle panels), and T_CM (right panels) in the AIM+ CD4+ or CD8+ T‐cell populations. Red circles: subjects responding to both CD4 and CD8 epitopes (#21, 23–27); gray circle: subjects responding to only CD8 epitopes (#22). Symbol represents the data derived from each individual subject. Seven subjects were studied in four independent experiments (one to three subjects/experiment depending upon enrollment). Medians were calculated and reported in the figure. T_EMRA were more numerous in antigen‐specific, AIM+ CD8+ T cells than in CD4+ T cells. T_EM and T_CM were more numerous in antigen‐specific, AIM+ CD4+ T cells than CD8+ T cells.