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. 2021 Oct 27;52(1):123–137. doi: 10.1002/eji.202149556

Figure 5.

Figure 5

CD4+ and CD8+ T‐cell responses to SARS‐CoV‐2 and CCC peptide megapools in KD children sampled before and during the COVID‐19 pandemic. CD4+ and CD8+ T‐cell responses to SARS‐CoV‐2 and CCC were tested in five KD subjects (#28–32) sampled before the COVID‐19 pandemic (2011–2016) and in five KD subjects (#33–37) sampled during the COVID‐19 pandemic (May–July, 2020). (A) CD4+ T‐cell responses to CD4 peptide megapools in each individual KD subject. Four (#28, 30–32) of the five KD subjects sampled before the pandemic showed no responses to any of the CD4 megapools derived from SARS‐CoV‐2 or CCC, and one (#29) responded only to CCC CD4 spike. Similarly, four (#33, 34, 36, 37) of the five KD subjects enrolled during the pandemic showed no responses to any of the CD4 megapools derived from SARS‐CoV‐2 or CCC, and one (#35) showed concurrent responses to CD4 spike and nonspike from both SRAS‐CoV‐2 and CCC. (B) CD8+ T‐cell responses to CD8 peptide megapools in each individual KD subject. None of the KD subjects enrolled before the pandemic showed detectable response to SARS‐CoV‐2 CD8 megapools. Symbols represent the data derived from each individual subject. Ten subjects were studied in three independent experiments (two to five subjects/experiment depending upon enrollment). Three (#35–37) of the KD subjects enrolled during the pandemic showed a low response to SARS‐CoV‐2 CD8 megpaools. Comparisons of the percentage of AIM+ T cells in the unstimulated control and peptide megapool‐stimulated cultures were tested by Wilcoxon rank sign test.