TABLE 3.
Simulated trough concentrations (median and 90% prediction intervals) of GS‐441524 at steady‐state by renal function
| Dosing regimen | Trough concentration (ng/ml) | |||
|---|---|---|---|---|
| Age | eGFRnon‐indexed | Regimen 1 | Regimen 2 | Regimen 3 |
| <75 | 15 ml/min | 670.3 (423.1–1030.5) | 351.9 (219.2–542.7) | 184.4 (96.9–296.2) |
| 30 ml/min | 370.5 (211.9–591.9) | 168.3 (83.8–286.8) | 66.0 (21.8–136.9) | |
| 60 ml/min | 158.2 (74.2–284.6) | 56.0 (18.6–119.7) | 13.3 (1.6–44.4) | |
| 90 ml/min | 85.3 (33.3–169.2) | 24.0 (4.8–63.0) | 3.4 (0.1–18.2) | |
Regimen 1: 200 mg on day 1 followed by 100 mg daily from day 2. Regimen 2: 200 mg on day 1 followed by 100 mg once every 2 days from day 2. Regimen 3: 200 mg on day 1 followed by 100 mg once every 4 days from day 2.
eGFRnon‐indexed, estimated glomerular filtration rate readjusted by individual body surface area.